Table 4. MiRNA target prediction.

The table lists the significant pathways containing RAC1, a protein known to be involved in AD and predicted to be targeted by 4 of the 5 trending miRNAs.

	Ingenuity Pathways	−log(p-value)
Neural	Axonal Guidance Signaling	6.24
	Synaptogenesis Signaling	4.82
	HGF Signaling	4.81
	NGF Signaling	4.65
	Opioid Signaling	4.06
	Endocannabinoid Developing Neuron	3.06
	GNRH Signaling	2.79
	Reelin Signaling in Neurons	2.55
	Amyotrophic Lateral Sclerosis Signaling	2.37
	Glucocorticoid Receptor Signaling	2.29
	Netrin Signaling	2.22
	Glioma Invasiveness Signaling	1.86
	Agrin Interactions at Neuromuscular Junction	1.68
	Semaphorin Signaling in Neurons	1.46
Glial	GDNF Family Ligand-Receptor Interactions	4.51
Immune Related	Systemic Lupus Erythematosus in B Cell Signaling	6.98
	fMLP Signaling in Neutrophils	4.55
	B Cell Receptor Signaling	4.49
	STAT3	4.16
	CCR3 Signaling in Eosinophils	4.15
	CXCR4 Signaling	3.82
	IL-3 Signaling	3.71
	Fc Epsilon RI Signaling	3.46
	Natural Killer Cell Signaling	3.37
	Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes	3.19
	IL-8 Signaling	3.15
	PI3K Signaling in B Lymphocytes	3.10
	Sphingosine-1-phosphate Signaling	2.98
	Macropinocytosis Signaling	2.75
	iCOS-iCOSL Signaling in T Helper Cells	2.31
	Fc${\widehat{I}}^3$ Receptor-mediated Phagocytosis in Macrophages and Monocytes	2.03
	Leukocyte Extravasation Signaling	1.85
	PKC$\widehat{I}$, Signaling in T Lymphocytes	1.83
	T Cell Receptor Signaling	1.70
	HMGB1 Signaling	1.61
	CD28 Signaling in T Helper Cells	1.33