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. 2022 Jun 23;50(12):7115–7133. doi: 10.1093/nar/gkac524

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Published by Oxford University Press on behalf of Nucleic Acids Research 2022.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 8. — Model. In proliferating (undifferentiated) myoblasts, lncRNA OIP5-AS1 levels are low, while miRNA miR-7 levels are high. As myogenic differentiation progresses, OIP5-AS1 levels rise, and through its extensively complementarity with miR-7, it induces miR-7 degradation via TDMD (right arm). The low levels of miR-7 in differentiated myoblasts then permit the rise in expression of the miR-7 target MYMX mRNA, which encodes the fusogenic protein MYMX and further promotes myotube fusion. Use of a TSB that masks the site of miR-7 binding on OIP5-AS1 (left arm) prevents miR-7 decay, in turn keeping MYMX mRNA unstable and repressing myogenesis. In sum, through a TDMD mechanism, OIP5-AS1 promotes fusogenic protein MYMX expression and enhances myotube formation.