Figure 6.

Diagram of the proposed mechanism of lipogenesis regulation by targeting of the G4 structure. (A) When ACBP gene starts to transcribe, the G4 structure forms and recruits transcription factors to turn on the transcription of ACBP. Then, ACBP proteins perform important functions in esterification and β-oxidation reaction. (B) The binding of transcription factors with G4 can be blocked by G4-specific binding compounds, such as PDS, or by mutation of the G4 structure by CRISPR–Cas9 to inhibit the expression of ACBP and result in reduced TAG levels and cell proliferation. Thus, the ACBP promoter G4 structure is a novel target for the development of insecticides and tumour-suppressive drugs.