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. 2022 Jun 23;50(12):6656–6670. doi: 10.1093/nar/gkac539

Figure 6.

Figure 6.

Modeling of modified guide strands in human Ago2. GNA-modified guide strand of D4 (A) or DNA-modified guide strand of D11 (B) modeled into the structure of Ago2–guide complex (PDB code 4F3T) (41). The angle of the kink in the guide strand introduced by Ile365 is indicated by the black dashed wedge. The same guide strands, now modeled into a structure of Ago2 in complex with both guide and target RNAs (PDB code 4W5T), are shown in panels (C) and (D) (7). A relax of the kink between g6 and g7 can be observed with a close to A-like conformation of the guide–target duplex.