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RISC assembly and the gene silencing pathways. AGO incorporates a miRNA duplex, ejects the passenger strand (green), and forms the RISC with the remaining guide strand (red). The effector complexes of all four human AGOs cause translational repression and mRNA degradation. Meanwhile, only AGO2 and AGO3 become a slicer, though target RNAs cleaved by AGO3-RISC remain unknown.
