Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 23;50(12):6618–6638. doi: 10.1093/nar/gkac519

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 13. — Differences in target recognition between AGO2 and AGO3. (A) Model of target cleavage by AGO2 loaded with a full-length guide. (B) Model of target cleavage by AGO3 loaded with cityRNA. (C) Flanking regions of the miRNA-binding site are required for AGO3, but not AGO2, to cleave target RNAs when they are programmed with full-length miRNAs.