Table 4.
Variable | Difference in glucose levels before PSM (n=165) |
Difference in glucose levels after PSM (n=108) |
Length of hospital stay (n=144) |
||||
---|---|---|---|---|---|---|---|
Β±SE | P value | Β±SE | P value | Β±SE | P value | ||
Univariable | |||||||
Groupa | –79.92±15.34 | <0.001b | –84.83±18.76 | <0.001b | –1.13±0.56 | 0.046b | |
Multivariable | |||||||
Groupa | –84.61±22.88 | <0.001b | –84.59±25.76 | 0.001b | –1.20±0.53 | 0.027b | |
Age, yr | –0.29±0.49 | 0.562 | –0.86±0.62 | 0.169 | –0.00±0.02 | 0.837 | |
BMI, kg/m2 | 3.19±2.02 | 0.117 | 1.54±2.37 | 0.519 | - | - | |
Classification (DKA)c | –27.80±22.91 | 0.227 | –35.76±27.97 | 0.204 | 0.52±0.78 | 0.505 | |
Classification (HHS)c | –27.09±23.40 | 0.249 | –33.38±28.48 | 0.244 | 1.64±0.81 | 0.043b | |
Classification (HHS with ketoacidosis)c | –14.423±22.26 | 0.518 | –21.64±27.85 | 0.439 | 0.38±0.75 | 0.613 | |
Dose of basal insulin, U | –0.66±1.53 | 0.669 | 0.38±1.71 | 0.825 | - | - | |
Duration of CIII, hr | –0.27±0.41 | 0.511 | –0.42±0.44 | 0.353 | 0.02±0.01 | 0.056 | |
Glucose level immediately before CIII discontinuation, mg/dL | –0.90±0.19 | <0.001b | –0.96±0.23 | <0.001b | - | - | |
Duration of DM, yr | 0.63±0.86 | 0.467 | 1.85±1.07 | 0.085 | –0.03±0.03 | 0.390 | |
Precipitating factor | –27.92±17.33 | 0.109 | –22.10±20.55 | 0.285 | 2.11±0.63 | 0.001b | |
OHA (metformin) | 3.79±22.97 | 0.869 | –0.95±27.07 | 0.972 | - | - | |
OHA (sulfonylurea) | 9.41±23.13 | 0.685 | 14.73±28.66 | 0.609 | - | - | |
OHA (DPP4 inhibitor) | –1.55±23.70 | 0.948 | –24.65±28.47 | 0.389 | - | - | |
OHA (SGLT2 inhibitor) | 3.71±40.16 | 0.927 | 21.15±45.66 | 0.645 | - | - |
B, β coefficient; SE, standard error; PSM, propensity score matching; BMI, body mass index; DKA, diabetic ketoacidosis; HHS, hyperosmolar hyperglycemic state; CIII, continuous intravenous insulin infusion; DM, diabetes mellitus; OHA, oral hypoglycemic agent; DPP4, dipeptidyl peptidase 4; SGLT2, sodium/glucose cotransporter 2.
Early vs. delayed basal insulin group;
Values are statistically significant (P<0.05) by linear regression analyses;
Data are compared to the category of severe hyperglycemia that did not satisfy the criteria for either DKA or HHS.