| Date of search |
10/3/2021 |
| Databases and other sources searched |
PubMed |
| Search terms used |
“variant histology bladder cancer” AND “radical cystectomy” AND “neoadjuvant chemotherapy” (“Urothelial carcinoma” OR “urothelial cancer” OR “bladder cancer” OR “bladder carcinoma”) AND (“variant” OR “differentiation” OR “VH”) AND (“multivariate OR multivariable”) |
| “transitional cell, carcinoma” AND “micropapillary variant” |
| “transitional cell, carcinoma” AND “plasmacytoid variant” |
| “transitional cell, carcinoma” AND “nested variant” |
| “transitional cell, carcinoma” AND “sarcomatoid variant” |
| “transitional cell, carcinoma” AND “lymphoepithelioma-like” |
| “transitional cell, carcinoma” AND “clear cell variant” |
| “transitional cell, carcinoma” AND “microcystic variant” |
| “transitional cell, carcinoma” AND “squamous differentiation” |
| “transitional cell, carcinoma” AND “glandular differentiation” |
| “Carcinoma, transitional cell/therapy” AND “neoadjuvant therapy/methods |
| Timeframe |
From inception till 10/3/2022 |
| Inclusion and exclusion criteria |
Inclusion criteria: Randomized clinical control trials (RCTs) and institutional observational studies reporting pathologic outcomes of histologic variant subtypes of urothelial carcinoma (UC) in non-metastatic disease or survival outcomes after cystectomy with or without neoadjuvant chemotherapy (NAC) |
| Exclusion criteria: Studies that queried non institutional databases, review articles, case reports or series with a variant histology sample size <10 |
