Table 1.
Genotype and allelic frequencies of selected SNPs in patients and controls
| Gene, rs | Group | n | Genotypes | P1 | Risk allele, % | P2 | ||
|---|---|---|---|---|---|---|---|---|
| MC4R rs17782313 | TT | CT | CC | C | ||||
| T2D | 121 | 78 (64.5%) | 33 (27.3%) | 10 (8.3%) | 0.05* | 21.9 | 0.24 | |
| Prediabetes | 88 | 54 (61.4%) | 29 (33.0%) | 5 (5.7%) | 0.46 | 22.2 | 0.32 | |
| Overweight | 95 | 54 (56.8%) | 39 (41.1%) | 2 (2.1%) | 0.33 | 22.6 | 0.37 | |
| Controls | 172 | 92 (53.5%) | 70 (40.7%) | 10 (5.8%) | 1.00 | 26.2 | 1.00 | |
| PPARG rs1801282 | CC | CG | GG | C | ||||
| T2D | 131 | 93 (71.0%) | 29 (22.1%) | 9 (6.9%) | 0.003* | 82.1 | 0.07 | |
| Prediabetes | 94 | 69 (73.4%) | 23 (24.5%) | 2 (2.1%) | 0.39 | 85.6 | 0.65 | |
| Overweight | 99 | 69 (69.7%) | 25 (25.3%) | 5 (5.1%) | 0.03* | 82.3 | 0.11 | |
| Controls | 257 | 192 (74.7%) | 63 (24.5%) | 2 (0.8%) | 1.00 | 87.0 | 1.00 | |
| TCF7L2 rs7903146 | CC | CT | TT | T | ||||
| T2D | 131 | 73 (55.7%) | 41 (31.3%) | 17 (13.0%) | 0.02* | 28.6 | 0.04 | |
| Prediabetes | 91 | 44 (48.4%) | 32 (35.2%) | 15 (16.5%) | 0.001* | 34.1 | 0.001* | |
| Overweight | 105 | 58 (55.2%) | 32 (30.5%) | 15 (14.3%) | 0.01* | 29.5 | 0.03* | |
| Controls | 404 | 246 (60.9%) | 135 (33.4%) | 23 (5.7%) | 1.00 | 22.4 | 1.00 | |
*p < 0.05, statistically significant differences between participants with metabolic disorders and controls