Table 4.

The MC4R rs17782313 genotypes and dynamics of body composition changes

Parameter, %	Diet therapy		P	Diet therapy + metformin		P
	TT (n = 30)	TC + CC (n = 14)		TT (n = 21)	TC + CC (n = 14)
Body weight	− 2.67 ± 0.59	− 1.03 ± 0.76	0.11	− 5.35 ± 0.89	− 2.5 ± 0.86	0.037*
BMI	− 3.19 ± 0.65	− 1.59 ± 0.87	0.16	− 5.91 ± 0.95	− 3.1 ± 1.22	0.04*
Waist circumference	− 4.56 ± 1.03	− 3.59 ± 1.16	0.57	− 5.48 ± 0.86	− 2.66 ± 1.66	0.11
Hip circumference	− 3.57 ± 1.09	− 2.41 ± 1.45	0.54	− 5.98 ± 1.03	− 2.07 ± 1.39	0.028*
Waist/hip ratio	− 1.28 ± 0.84	− 1.94 ± 1.40	0.67	− 0.20 ± 0.74	− 0.99 ± 1.11	0.54
Fat mass	− 1.09 ± 0.26	− 0.42 ± 0.26	0.12	− 1.6 ± 0.28	− 0.65 ± 0.26	0.027*
Total water	+ 0.006 ± 0.11	+ 0.06 ± 0.12	0.78	− 0.43 ± 0.19	− 0.3 ± 0.15	0.61
Body cell mass	− 0.17 ± 0.08	− 0.10 ± 0.09	0.62	− 1.03 ± 0.17	− 1.33 ± 0.15	0.60

Data are mean ± SEM

*p < 0.05, statistically significant differences