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. Author manuscript; available in PMC: 2022 Sep 25.
Published in final edited form as: Mucosal Immunol. 2022 Mar 25;15(4):683–697. doi: 10.1038/s41385-022-00502-1

Fig 8. Intestinal epithelial VDR overexpression mice have fewer and smaller tumors and show protection from decreased Claudin-5 and increased inflammation.

Fig 8.

(A) Colonic tumors in situ. Representative colons from different groups. Tumors were indicated by red arrows. (B) Tumor numbers in AOM-DSS induced colon cancer model: O-VDRloxp and O-VDR mice (data are expressed as mean ± SD. n = 4-7, one-way ANOVA test,). (C) Max tumor size in AOM-DSS induced colon cancer model: O-VDRloxp and O-VDR mice (data are expressed as mean ± SD. n = 4-7, one-way ANOVA test). (D) Claudin-5 at the mRNA and (E) protein levels were decreased in the tumor tissue than in the control mice. O-VDRloxp mice tumor tissue had much more decrease than the O-VDR mice (data are expressed as mean ± SD. n = 3, one-way ANOVA test). (F) The inflammatory cytokines IL-1β and IL-17 were less increased in the AOM/DSS-induced O-VDR mice colon cancer model, than the levels in O-VDRloxp mice (data are expressed as mean ± SD. n = 3, one-way ANOVA test). All p values are shown in the figure.