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. Author manuscript; available in PMC: 2022 Jul 8.
Published in final edited form as: Ann Rheum Dis. 2022 Apr 12;81(7):1006–1012. doi: 10.1136/annrheumdis-2021-221985

Figure 6. Decreased expression of IL-21, CD40L, pSTAT3 and Bcl-6 in splenic Tfh cells of MRL/lpr mice treated with MCC950.

Figure 6.

(A) Serum IL-21 level was significantly lower in MCC950-treated group than that in vehicle group. (B) and (C) The expressions of IL-21 in Tfh cells was also significantly lower in the MCC950-treated group. (D)–(I) Similar increases of CD40L, pSTAT3 and Bcl-6 expressions in Tfh cells were detected. These increases were inhibited by MCC950.