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. 2022 Apr 11;12(7):1676–1689. doi: 10.1158/2159-8290.CD-21-1615

Figure 1.

Figure 1. Modeling of sunvozertinib with EGFR exon20ins 770_NPG (PDB code: 4LRM). Key interactions of sunvozertinib with EGFR proteins include (i) bidentate interactions of aminopyrimidine with a hinge (Met796); (ii) acrylamide group forms an irreversible covalent bond with Cys797; (iii) 2-hydroxypropan-2-yl group occupy space next to c-helix; (iv) polar interaction of dimethylaminopyrrolidine with solvent channel residues. Green: carbon; purple: nitrogen; red: oxygen; dark green: chloride; light blue: fluorine. Colors on the protein surface represent the ATP-binding pocket and are for clarity only.

Modeling of sunvozertinib with EGFRexon20ins 770_NPG (Protein Data Bank code: 4LRM). Key interactions of sunvozertinib with EGFR proteins include (i) bidentate interactions of aminopyrimidine with a hinge (Met796), (ii) acrylamide group forms an irreversible covalent bond with Cys800, (iii) 2-hydroxypropan-2-yl group occupies space next to the C-helix, and (iv) polar interaction of dimethylaminopyrrolidine with solvent channel residues. Green: carbon; purple: nitrogen; red: oxygen; dark green: chloride; light blue: fluorine. Colors on the protein surface represent the ATP-binding pocket and are for clarity only. DZD9008 = sunvozertinib.