Skip to main content
. 2022 Apr 22;20(7):1013–1020. doi: 10.1158/1541-7786.MCR-21-0683

Figure 1.

Figure 1. Phasing of somatic mutations to determine gene-level haplotype. A, Schematic of gene-level haplotype, derived from phased linked read sequencing data, distinguishes between genes with multiple heterozygous mutations on the same or different alleles. Dark blue or light blue bars represent each allele for a given gene. Red and green stars indicate examples for the positions of mutations. B, Somatic mutations on “Longtail” genes previously found to be recurrently mutated in prostate cancer (4) stratified by gene-level haplotype. C, Cell line mutations in the Longtail panel of cancer driver genes that are recurrently mutated in human prostate cancer, with variant classification for each mutation, and gene-level haplotype for each gene annotated for each cell line. D, Lollipop plots showing locations of JAK1 and CDK12 biallelic heterozygous mutations relative to positions of Pfam domains. Colors of the lollipop heads indicate the variant classification for each mutation (blue = frameshift; green = missense).

Phasing of somatic mutations to determine gene-level haplotype. A, Schematic of gene-level haplotype, derived from phased linked read sequencing data, distinguishes between genes with multiple heterozygous mutations on the same or different alleles. Dark blue or light blue bars represent each allele for a given gene. Red and green stars indicate examples for the positions of mutations. B, Somatic mutations on “Longtail” genes previously found to be recurrently mutated in prostate cancer (4) stratified by gene-level haplotype. C, Cell line mutations in the Longtail panel of cancer driver genes that are recurrently mutated in human prostate cancer, with variant classification for each mutation, and gene-level haplotype for each gene annotated for each cell line. D, Lollipop plots showing locations of JAK1 and CDK12 biallelic heterozygous mutations relative to positions of Pfam domains. Colors of the lollipop heads indicate the variant classification for each mutation (blue = frameshift; green = missense).