Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 7;13:3913. doi: 10.1038/s41467-022-31635-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — A Representative images of parvalbumin (PV), aromatase (Arom) and WFA staining (perineuronal nets, PNNs) in adult female mice CA1 region. WFA staining was used to reveal the presence (arrows) or absence (arrowheads) of PNNs surrounding parvalbumin inhibitory neurons (PV-INs). Scale bar: 20 μm. B Proportion of PV-INs surrounded by PNNs (left plot). Higher aromatase levels were detected in PNN⁺ PV-INs as compared with PNN⁻ PV-INs (right plot). Unpaired two-tailed t-test, *p < 0.0001, t(168) = 4.3; n = 170 PV-IN from 3 female mice. C Proportion of aromatase expressing (Arom⁺) neurons was higher in PNN⁺ PV-INs (upper plot) compared with PNN⁻ PV-INs (lower plot). Two-sided Fisher’s exact test, p < 0.0001; n = 170 PV-IN from 3 female mice. D Representative images of PV, aromatase and SATB1 staining in adult female mice CA1 region. Arrow points to a SATB1⁺ PV-IN. Arrowheads point to SATB1⁻ PV-INs. Scale bar: 20 μm. E Proportion of PV INs expressing SATB1 (left plot). Higher aromatase levels were detected in SATB1⁺ PV-INs as compared with SATB1⁻ PV-INs (right plot). Two-tailed Mann–Whitney test, U = 3304, p < 0.0001; n = 245 PV-INs from 3 female mice. F Proportion of aromatase expressing (Arom⁺) neurons was higher in SATB1⁺ PV-INs (upper plot) compared with SATB1⁻ PV-INs (lower plot). Two-sided Fisher’s exact test, p < 0.0001; n = 245 PV-IN from 3 female mice. Whisker in plots represent median and 10–90 percentiles. *p < 0.05. Source data are provided as a Source Data file.