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. 2022 Jul 7;13:3919. doi: 10.1038/s41467-022-31646-0

Fig. 5. Therapeutic effect of Ac2–26 in UHMWPE debris-induced inflammatory osteolysis model.

Fig. 5

Debris was implanted and the calvarial bone of mice were then treated with BML111 (1 mg/kg), WRW4 (2.5 mg/kg) and Ac2–26 (1 mg/kg). a Quantification of the lytic area in calvarial bone tissues analyzed by micro-CT. Results represent the mean ± SEM of 7 mice. b, c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone tissues. Significant difference among the groups was determined by one-way ANOVA, followed by Tukey’s multiple-comparison procedure. *p < 0.05, **p < 0.001, ***p < 0.0001, ****p < 0.00001. ns indicates no significant difference. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. Source data are provided as a Source Data file.