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Interaction between ACSS2 and AMPK. Energy stress and acetate promote the phosphorylation and activation of AMPK. AMPK phosphorylates ACSS2 at S659 and leads to its nuclear translocation. Nuclear ACSS2 and TFEB form a complex that additionally acetylates histones through the production of acetyl-CoA. ACSS2 drives AMPK activation by converting acetate and ATP to acetyl-CoA and AMP
