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. 2022 Jun 24;13:851167. doi: 10.3389/fendo.2022.851167

Table 2.

Pregnancy outcomes of triplets reduced to singletons versus triplets reduced to twins.

Triplets reduced to singleton(n=45) Triplets reduced to twins(n=331) Unadjusted P Value Unadjusted OR(95%CI) Adjusted P Value Adjusted OR(95% CI)
GA at delivery 39.07 (38.25-40.04) 37.00 (35.71-37.86) <0.001 <0.001
Delivery<32weeks 1 (2.2) 17 (5.1) 0.626 0.42 (0.06-3.23) 0.412 0.75 (0.37-1.50)
Delivery<34weeks 2 (4.4) 38 (11.5) 0.239 0.36 (0.08-1.54) 0.206 0.73 (0.44-1.19)
Delivery<37weeks 6 (13.3) 150 (45.3) <0.001 0.19 (0.08-0.45) <0.001 0.58 (0.43-0.79)
Pregnancy loss <24weeks 3 (6.7) 22 (6.6) 1.000 1.00 (0.19-3.50) 0.701 0.92 (0.59-1.42)
All surviving 42 (93.3) 263 (79.5) 0.026 3.62 (1.09-12.03) 0.023 1.62 (1.07-2.44)
Caesarean section 28/42 (66.7) 290/309 (93.9) <0.001 0.13 (0.06-0.29) <0.001 0.51 (0.38-0.67)
Birth weight (g) 3050 (2775-3300) 2500 (2200-2800) <0.001 <0.001
At least one LBW 4 (8.9) 176 (53.2) <0.001 0.09 (0.03-0.25) <0.001 0.44 (0.31-0.63)
At least one VLBW 0 11 (3.3) 0.441 0.997
At least one SGA 8 (17.8) 148 (44.7) 0.001 0.27 (0.12-0.59) 0.001 0.62 (0.48-0.82)

Data are presented as median (IQR) or number (%). Mann–Whitney U tests and Chi-square tests or Fisher’s exact test were used for unadjusted analysis. Logistic regression and linear regression were used for adjusting certain confounders, including maternal age at conception, maternal BMI before pregnancy, type of infertility, ART methods, embryo transplantation, source of semen, and weeks of reduction.

GA, gestational age; LBW, low birth weight; VLBW, very low birth weight; SGA, small for gestational age; OR, odds ratio; CI, confidence interval.