TABLE 3.

Univariable and multivariable Cox analysis of 5-year all-cause death risk according to clinical characteristics, biomarkers and echocardiographic parameters.

Variable	Univariable analysis			Multivariable analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Age, years	1.033	0.999–1.069	0.055	1.021	0.980–1.063	0.325
Sex (Men)	1.596	0.837–3.043	0.156
Kidney involvement	0.806	0.422–1.537	0.512
Septal wall thickness, mm	1.184	1.036–1.353	0.013	1.154	0.983–1.356	0.080
LV ejection fraction,%	0.972	0.943–1.003	0.072	0.953	0.913–0.995	0.028
E/e’	1.012	0.987–1.038	0.365	0.999	0.965–1.034	0.950
Δ troponin T, ng/dL	0.039	<0.001–7.454	0.226
Δ dFLC, mg/L	1.000	1.000–1.000	0.852
Post NT-proBNP/Pre NT-proBNP	1.289	1.171–1.417	<0.001	1.252	1.065–1.472	0.007
Δ [LV GLS],%	0.844	0.757–0.940	0.002	0.819	0.714–0.940	0.004

CI, confidence interval; dFLC, difference between involved and uninvolved serum free light chains; Δ dFLC, post-chemotherapy dFLC—pre-chemotherapy dFLC; E, early diastolic mitral inflow velocity; e’, early diastolic mitral annular tissue velocity; HR, hazard ratio; LV, left ventricular; [LV GLS], absolute value of left ventricular global longitudinal strain; Δ [LV GLS], post-chemotherapy [LV GLS]—pre-chemotherapy [LV GLS]; NT-proBNP, N-terminal pro-brain natriuretic peptide; Δ troponin T, post-chemotherapy troponin T—pre-chemotherapy troponin T. The values in bold indicate statistical significance (p < 0.05).