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. 2022 Jul 7;13(7):586. doi: 10.1038/s41419-022-05035-w

Fig. 3. Effects of CHST15 mutation on JAK2V617F allele burdens and proteins expression of p-stat3, p-stat5 and p-p38 on PBMNCs from familial MPNs (n = 5), sporadic MPNs (n = 50).

Fig. 3

A1 Histograms show significantly increased JAK2V617F allele burdens in familial MPNs with CHST15 mutation (p = 0.016). A2 Histograms indicate upregulated p-stat3 expression in familial MPNs corresponding to sporadic MPNs (n = 15) (p < 0.001); but no statistic difference is found for p-state5 and p-p38 between familial MPNs and sporadic MPNs. B1/B2: A representative FCM figures for p-stat3 and p-stat5 assays. Data are presented as mean ± s.e.m. ***p < 0.001; *p < 0.05, Student’s t test. C Western blot results show that cells harbouring CHET15 mutation present upregulated expression of p-stat3.