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. 2022 Jun 24;14:846902. doi: 10.3389/fnagi.2022.846902

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Copyright © 2022 Morgan, Naderi, Koler, Pita-Juarez, Prokopenko, Vlachos, Tanzi, Bertram and Hide.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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All pathways ordered by the log of their total paper counts associating them with AD or dementia. We have colored each bar to represent the percentage of papers containing an adequate number of AD-relevant words (purple), dementia terms (pink), dementia caused by related disorders (orange), and unrelated dementias (yellow). Pathways with only 1 study do not display on this scale. The average percentage of AD-specific studies per pathway was 64% excluding those with less than 50 studies. The highest proportions were found in ABC transporters (88%), Alzheimer’s disease (95%), the glycosaminoglycan pathways (93–94%), and the O-glycan pathways (98%). These data are summarized in Supplementary Table 4.