TABLE 4.
Top six molecular pathways involving overexpressed miRNAs targeting TP53 and RB1 genes.
| KEGG Pathway | p-Value pathway | miRNAs name | Target gene | p-Value interaction |
|---|---|---|---|---|
| Viral carcinogenesis (hsa05203) | <1.00 × 10−325 | let-7a-5p | TP53 and RB1 | 1.16 × 10−10 |
| miR-130a-3p | RB1 | 0.0039733 | ||
| miR-16-5p | TP53 | 6.44 × 10−08 | ||
| miR-205-5p | TP53 | 6.44 × 10−08 | ||
| miR-22-3p | TP53 | 6.44 × 10−08 | ||
| miR-93-5p | TP53 and RB1 | 1.16 × 10−10 | ||
| Central carbon metabolism in cancer (hsa05230) | 3.39 × 10−06 | let-7a-5p | TP53 | 0.0011443 |
| miR-16-5p | TP53 | 0.0005629 | ||
| miR-205-5p | TP53 | 0.0005629 | ||
| miR-22-3p | TP53 | 0.0005629 | ||
| miR-93-5p | TP53 | 0.0011443 | ||
| Chronic myeloid leukemia (hsa05220) | 1.33 × 10−05 | let-7a-5p | TP53 and RB1 | 0.0005998 |
| miR-16-5p | TP53 | 0.0041602 | ||
| miR-205-5p | TP53 | 0.0041602 | ||
| miR-22-3p | TP53 | 0.0041602 | ||
| miR-93-5p | TP53 and RB1 | 0.0005998 | ||
| Glioma (hsa05214) | 0.0064303 | let-7a-5p | TP53 and RB1 | 0.0017756 |
| miR-130a-3 | RB1 | 0.0105785 | ||
| miR-93-5p | TP53 and RB1 | 0.0017756 | ||
| Melanoma (hsa05218) | 0.0120334 | let-7a-5p | TP53 and RB1 | 0.0041201 |
| miR-93-5p | TP53 and RB1 | 0.0041201 | ||
| Cell cycle (hsa04110) | 0.0224147 | let-7a-5p | TP53 and RB1 | 0.0038093 |
| miR-130a-3 | RB1 | 0.0014269 | ||
| miR-93-5p | TP53 and RB1 | 0.0038093 |