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. 2022 Jun 24;9:919187. doi: 10.3389/fmolb.2022.919187

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Copyright © 2022 Li, Yang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory signaling pathways implicated in ferroptosis. The features of ferroptosis include the substrate of lipid peroxidation (PUFA), executor of lipid peroxidation (iron metabolism), and anti-ferroptosis systems (GPX4-centered and p53-centered systems). ACSL4, acyl-CoA synthetase long-chain family member four; DDP4, dipeptidyl peptidase-4; DMT1, divalent metal transporter 1; FSP1, ferroptosis suppressor protein 1; GPX4, glutathione peroxidase four; GSH, glutathione; HO-1, heme oxygenase 1; iASPP, inhibitor of apoptosis stimulating protein of p53; iFSP1, FSP1 inhibitor 1; LOXs, lipoxygenases; LPCAT3, lysophosphatidylcholine acyltransferase three; NRF2, nuclear factor erythroid 2-related factor 2; NCOA4, nuclear receptor coactivator four; PCBP, poly (RC)-binding proteins; PUFA, polyunsaturated fatty acid; ROS, reactive oxygen species; SLC3A2, solute carrier family three member 2; SLC7A11, solute carrier family seven member 11; STEAP3, six-transmembrane epithelial antigen of prostate three; VDACs, voltage-dependent anion channels.