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Comparison of GBE2.0 developed in this study with recently reported advanced GBEs
(A) The C-to-G base editing efficiency of GBE2.0 and CGBEs from 8 loci (gRNA for C6 sites). (B) The average C-to-G base editing efficiency of GBE2.0 and CGBEs from 8 loci (gRNA for C6 sites). ∗∗p < 0.01 was considered statistically significant. The bars represent the average editing efficiency, and error bars represent the SD of 3 independent biological replicates.
