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Proposed algorithm for SGLT2 inhibitor initiation. ∗Consider earlier bloodwork in higher risk: stage ≥3B CKD, prior episode(s) of acute kidney injury, or at risk for volume depletion. ACE, angiotensin-converting enzyme; ARB, angiotensin II receptor blocker; ARNI, angiotensin receptor-neprilysin inhibitor; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; MRA, mineralocorticoid receptor antagonist.
