Table 3.
Summary histopathology by etiologic diagnosis of VR
| Category | AM-VR | Mixed VR | TCM-VR |
|---|---|---|---|
| Biopsies (n) | 21 | 36 | 43 |
| Time (mo) | 34.8 ± 77.3 | 14.4 ± 39.7 | 8.8 ± 26.5a |
| Indication, n (%) | 14 (66.7) | 28 (77.8) | 20 (46.5)b |
| Serum creatinine (μmol/l) | 302 ± 225 | 324 ± 274 | 252 ± 219 |
| Mean MFI (nil DSA = 0) | 4776 ± 7494 | 3680 ± 5157 | 348 ± 827b,c |
| Banff v score | 1.5 ± 0.8 | 1.2 ± 0.5 | 1.2 ± 0.4 |
| Banff ti score | 0.7 ± 0.7 | 2.2 ± 0.9c | 0.8 ± 0.9d |
| Banff i score | 0.2 ± 0.4 | 2.1 ± 0.7c | 0.6 ± 0.9d |
| Banff t score | 0.5 ± 0.6 | 1.8 ± 0.7c | 0.9 ± 0.8d |
| Banff ptc score | 0.6 ± 0.9 | 1.2 ± 1.0a | 0.2 ± 0.5d |
| Banff g score | 0.4 ± 0.9 | 0.7 ± 0.9 | 0.3 ± 0.6e |
| C4dptc score | 0.7 ± 1.0 | 0.6 ± 0.8 | 0 ± 0b,c |
| C4dglom score | 0.7 ± 0.9 | 0.5 ± 0.9 | 0.2 ± 0.4a,b |
| C4dart score | 1.1 ± 0.7 | 1.4 ± 0.9 | 0.0 ± 0.3c,d |
| Recurrent rejection, n (%)f | 7 (33.3) | 12 (33.3) | 15 (34.9) |
| Graft failure, n (%)f | 5 (23.8) | 10 (27.8) | 3 (7.0)e |
AM-VR, antibody-mediated vascular rejection; C4dart, C4d staining of arterial endothelium and intima; C4dglom, endothelial C4d staining of glomerular capillaries; C4dptc, C4d staining of peritubular capillaries; MFI, median fluorescence intensity; TCM-VR, T-cell–mediated vascular rejection; VR, vascular rejection.
Detailed histopathology of VR classified by pathophysiology. Mean ± SD, n (%).
Key:
a
P < 0.05; versus AM-VR (pure).
b
P < 0.01; versus mixed VR.
c
P < 0.001 versus AM-VR (pure).
d
P < 0.001 versus mixed VR.
e
P < 0.05; versus mixed VR.
f
Graft failure and recurrent rejection denominator is per biopsy (including repeat biopsies).