Table 4.
Pathways enriched for DEGs identified between CoV2+ and CoV2- groups (nominal p-value < 0.05).
| Category | Term | Genes | p-value |
|---|---|---|---|
| KEGG_PATHWAY | hsa04612:Antigen processing and presentation | HSPA8, CD74, HLA-B, PSME2, HLA-DQA1, CTSB, HLA-DQB1 | 0.0002 |
| REACTOME_PATHWAY | R-HSA-114608:R-HSA-114608:Platelet degranulation | TGFB1, HSPA5, SERPING1, TAGLN2, PPBP, THBS1, F5 | 0.0019 |
| KEGG_PATHWAY | hsa04621:NOD-like receptor signaling pathway | RIPK2, IL1B, NLRP3, CXCL1, CXCL2 | 0.0033 |
| KEGG_PATHWAY | hsa04668:TNF signaling pathway | RPS6KA4, IL1B, CXCL1, PTGS2, CXCL2, CREB5 | 0.0064 |
| KEGG_PATHWAY | hsa04145:Phagosome | FCGR3A, TFRC, HLA-B, THBS1, HLA-DQA1, HLA-DQB1 | 0.0247 |
| KEGG_PATHWAY | hsa05164:Influenza A | IVNS1ABP, HSPA8, IL1B, NLRP3, HLA-DQA1, HLA-DQB1 | 0.0428 |
| REACTOME_PATHWAY | R-HSA-1257604:R-HSA-1257604:PIP3 activates AKT signaling | IRS2, NRG1, EREG, HBEGF | 0.0475 |
| KEGG_PATHWAY | hsa05168:Herpes simplex infection | CD74, EEF1D, IL1B, HLA-B, HLA-DQA1, HLA-DQB1 | 0.0512 |
| REACTOME_PATHWAY | R-HSA-877300:R-HSA-877300:Interferon gamma signaling | HLA-B, TRIM21, HLA-DQA1, HLA-DQB1 | 0.0582 |
| REACTOME_PATHWAY | R-HSA-202424:R-HSA-202424:Downstream TCR signaling | RIPK2, PSME2, HLA-DQA1, HLA-DQB1 | 0.0807 |
Pathway enrichment analysis was conducted using the Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.8 and KEGG and Reactome databases. Pathways with nominal p-value < 0.1 were considered significant. Pathways identified from both databases were combined and sorted by the nominal p-value.