Figure 5.

Effects of APOL1 ASO treatment on renal inflammation in NEFTA/G2APOL1 mice

(A–H) The relative transcript level of NLR family pyrin domain containing 3 (Nlrp3) (A), stimulator of interferon genes (Sting or Tmem173) (B), interferon regulatory factor 3 (Irf3) (E), signal transducer and activator of transcription 3 (Stat3) (F), Interleukin 1 beta (Il1b) (G), signal transducer and activator of transcription 1 (Stat1) (H) in whole kidney lysates of NEFTA/G2APOL1 mice treated with control ASO, APOL1 ASO1, or ASO2, ∗p ≤ 0.05 versus control ASO-treated mice. The correlation of relative transcript levels of APOL1 and Nlrp3 (C) and Sting (D) in ASO-treated NEFTA/G2APOL1 mice.