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. 2022 Apr 6;7(7):1502–1513. doi: 10.1016/j.ekir.2022.03.026

Figure 1.

Figure 1

Figure 1

(a) HR of urine KIM-1, albumin, and UMOD collected during hospitalization in patients with AKI with composite CKD outcome using different approaches to account for urine concentration. (b) HR of urine biomarkers collected during hospitalization in patients without AKI with composite CKD outcome using different approaches to account for urine concentration. ∗P < 0.01 compared with biomarker’s association with composite CKD outcome when urine creatinine or osmolarity is accounted for versus biomarker alone. #The difference between biomarker’s association with composite CKD outcome when using urine creatinine versus urine osmolarity was insignificant in any model (P > 0.01 for all comparisons). All urine measurements were converted to log-2 base normally distributed Z score. HR therefore represents change per 1 SD increase of each biomarker on its log-2 scale. AKI, acute kidney injury; CKD, chronic kidney disease; Cr, creatinine; HR, hazard ratio; KIM-1, kidney injury molecule-1; Osm, osmolarity; UCr, urine creatinine; UMOD, uromodulin; UOsm, urine osmolarity.