TABLE 4.
Comparison of the relationship between each SNP and the efficacy of acitretin alone or the efficacy of acitretin treating secondary non-response to TNF-a biological agents.
| SNP | Therapy | Genotype | Noneffective | Effective | χ2 | Sig |
|---|---|---|---|---|---|---|
| Rs763780 | T&A | TT | 12 | 1 | 5.096 | 0.071 |
| CT | 1 | 2 | — | — | ||
| CC | 2 | 1 | — | — | ||
| A | TT | 17 | 4 | — | 0.143 | |
| CT | 1 | 2 | — | — | ||
| Rs4819554 | T&A | AG | 5 | 2 | 2.348 | 0.480 |
| AA | 4 | 2 | — | — | ||
| GG | 6 | 0 | — | — | ||
| A | AG | 4 | 3 | 2.150 | 0.391 | |
| AA | 10 | 3 | — | — | ||
| GG | 4 | 0 | — | — | ||
| Rs11209032 | T&A | AA | 1 (a) | 2 (a) | 6.577 | 0.020* |
| AG | 10 (b) | 0 (b) | — | — | ||
| GG | 4 (a, b) | 2 (a, b) | — | — | ||
| A | AA | 5 | 3 | 1.317 | 0.699 | |
| AG | 10 | 2 | — | — | ||
| GG | 3 | 1 | — | — | ||
| Rs6887695 | T&A | CC | 2 | 0 | 1.393 | 0.740 |
| CG | 7 | 1 | — | — | ||
| GG | 6 | 3 | — | — | ||
| A | CC | 1 | 1 | 1.214 | 0.792 | |
| CG | 11 | 3 | — | — | ||
| GG | 6 | 2 | — | — | ||
| Rs3212227 | T&A | TT | 5 | 2 | — | 0.603 |
| TG | 10 | 2 | — | — | ||
| A | GG | 13 (b) | 1 (a) | 6.124 | 0.035* | |
| TT | 3 (a) | 2 (a) | — | — | ||
| TG | 2 (b) | 3 (a) | — | — | ||
| Rs2201841 | T&A | GG | 8 | 2 | 0.723 | 1.000 |
| AG | 6 | 2 | — | — | ||
| AA | 1 | 0 | — | — | ||
| A | GG | 14 | 5 | — | 1.000 | |
| AG | 4 | 1 | — | — |
T&A: treated with TNF-a, monoclonal antibody plus acitretin. A: treated with acitretin alone. (a), (b), (a, b): no significant differences existed between any groups with the same letters, and significant differences existed only if the letters were completely different.