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. 2022 Jun 24;14:916633. doi: 10.3389/fnagi.2022.916633

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Copyright © 2022 Tang, Zhang, Liu, Xue, Ren, Huang, Shi and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receiver operating characteristic (ROC) curves used to predict cerebral small vessel disease (CSVD) cognitive impairment with the combination of the diffusion tensor image analysis along the perivascular space (ALPS) index and WMLs. Only the ALPS index and white matter lesions (WMLs) remained in the backward stepwise logistic regression model. The area under the receiver operating characteristic (AUROC) of the ALPS index and WMLs combined is 0.780 (blue), the AUROC of WMLs alone is 0.714 (green), and the AUROC of the ALPS index alone is 0.694 (red).