Table 5.
Comparison of antibiotics susceptibility of causative agents between the 2 phases
| Microorganism | Phase I (1998–2007) | Phase II (2008–2017) | P value | OR (95% CI) |
|---|---|---|---|---|
| Gram-positive bacteria | ||||
| Staphylococcus aureus | ||||
| Penicillin | 1/52 (1.9) | 2/57 (3.5) | 1.000b) | 1.855 (0.163–21.076) |
| Cefotaxime | 12/52 (23.1) | 8/12 (66.7) | 0.006b) | 6.667 (1.707–26.042) |
| Oxacillin | 10/52 (19.2) | 33/57(57.9) | <0.001a) | 5.775 (2.426–13.746) |
| CoNS | ||||
| Penicillin | 1/114 (0.9) | 0/350(0.0) | 0.246b) | 0.991 (0.974–1.008) |
| Cefotaxime | 3/105 (2.9) | 1/51 (2.0) | 1.000b) | 0.680 (0.069–6.704) |
| Oxacillin | 3/114 (2.6) | 10/350(2.9) | 1.000b) | 1.088 (0.294–4.025) |
| Gram-negative bacteria | ||||
| Klebsiella pneumoniae | ||||
| Gentamicin | 9/30 (30.0) | 26/31 (83.9) | <0.001a) | 12.133 (3.528–41.729) |
| Cefotaxime | 6/30 (20.0) | 20/31 (64.5) | 0.001a) | 7.273 (2.284–23.160) |
| Ceftriaxone | 6/30 (20.0) | 16/20 (80.0) | <0.001a) | 16.000 (3.889–65.830) |
| Enterobacter cloacae | ||||
| Gentamicin | 5/20 (25.0) | 10/10 (100.0) | <0.001a) | 0.250 (0.117–0.534) |
| Cefotaxime | 5/20 (25.0) | 8/10 (80.0) | 0.007b) | 12.000 (1.885–76.376) |
| Ceftriaxone | 5/20 (25.0) | 5/6 (83.3) | 0.018b) | 15.000 (1.397–161.045) |
| Escherichia coli | ||||
| Gentamicin | 5/14 (35.7) | 7/14 (50.0) | 0.704a) | 1.800 (0.396–8.182) |
| Cefotaxime | 7/13 (53.8) | 6/14 (42.9) | 0.568a) | 0.643 (0.141–2.938) |
| Ceftriaxone | 7/14 (50.0) | 2/5 (40.0) | 1.000b) | 0.667 (0.084–5.301) |
Values are presented as number (%).
OR, odds ratio; CI, confidence interval; CoNS, coagulase-negative Staphylococcus.
a)
Chi-square test.
b)
Fisher extract test.
Boldface indicates a statistically significant difference with P<0.05.