TABLE 3.
Statistically significant medically relevant AEs associated with the Janssen, Moderna, and Pfizer COVID-19 vaccines.
| Adverse Event | Vaccine | Count | PRR | x 2 |
|---|---|---|---|---|
| Behavioral and neurological AE (38) Janssen (22) Moderna (6) Pfizer (23) | ||||
| Ageusia | Janssen | 439 | 2.13 | 241.48 |
| Moderna | 1866 | 2.08 | 654.59 | |
| Pfizer | 2,381 | 3.26 | 1944.30 | |
| Anosmia | Janssen | 344 | 2.18 | 199.33 |
| Pfizer | 2007 | 3.92 | 2070.10 | |
| Anxiety | Pfizer | 4,279 | 2.21 | 1763.70 |
| Cold sweat | Janssen | 659 | 2.50 | 535.31 |
| Dysgeusia | Pfizer | 3,391 | 2.64 | 1985.12 |
| Fatigue | Janssen | 10,913 | 2.01 | 5,538.40 |
| Moderna | 47,860 | 2.00 | 16,620.00 | |
| Impaired work ability | Janssen | 656 | 2.20 | 393.88 |
| Moderna | 2,714 | 2.09 | 964.26 | |
| Nervousness | Pfizer | 1,212 | 2.05 | 411.43 |
| Night sweats | Janssen | 314 | 2.04 | 151.81 |
| Panic attack | Janssen | 139 | 2.13 | 76.22 |
| Pfizer | 672 | 2.64 | 391.61 | |
| Bell’s palsy | Moderna | 1,384 | 2.21 | 558.43 |
| Pfizer | 1728 | 3.36 | 1,467.30 | |
| Facial paralysis | Janssen | 274 | 2.10 | 144.77 |
| Pfizer | 1,333 | 2.61 | 761.59 | |
| Seizure | Janssen | 650 | 2.50 | 527.36 |
| Pfizer | 2,373 | 2.10 | 860.96 | |
| Chills | Janssen | 11,387 | 2.31 | 8,299.80 |
| Moderna | 12,512 | 19.19 | 15,573.00 | |
| Chest discomfort | Pfizer | 8,180 | 2.59 | 4,673.10 |
| Head discomfort | Janssen | 362 | 2.58 | 315.13 |
| Pfizer | 1,531 | 2.83 | 1,008.7 | |
| Limb discomfort | Moderna | 2,380 | 2.17 | 929.03 |
| Oropharyngeal discomfort | Pfizer | 781 | 3.41 | 675.46 |
| Throat irritation | Pfizer | 3,323 | 2.57 | 1854.5 |
| Disorientation | Janssen | 308 | 2.08 | 157.98 |
| Vertigo | Pfizer | 3,859 | 2.13 | 1,450.80 |
| Feeling abnormal | Janssen | 2,474 | 2.11 | 1,340.3 |
| Feeling of body temperature change | Janssen | 217 | 2.87 | 234.21 |
| Hypoesthesia oral | Pfizer | 2,604 | 2.79 | 1,679.20 |
| Axillary pain | Pfizer | 3,002 | 2.68 | 1802.00 |
| Breast pain | Pfizer | 1,017 | 2.95 | 716.01 |
| Chest pain | Pfizer | 11,968 | 2.52 | 6,524.10 |
| Eye pain | Janssen | 425 | 2.11 | 227.26 |
| Headache | Janssen | 15,890 | 2.24 | 11,188.00 |
| Migraine | Janssen | 1,239 | 2.71 | 1,198.10 |
| Pfizer | 4,132 | 2.04 | 1,396.60 | |
| Lymph node pain | Pfizer | 2,702 | 3.02 | 1977.50 |
| Oropharyngeal pain | Pfizer | 6,060 | 2.07 | 2,141.30 |
| Parosmia | Janssen | 138 | 2.25 | 87.37 |
| Pfizer | 704 | 3.19 | 556.56 | |
| Sensory disturbance | Janssen | 224 | 2.60 | 196.94 |
| Throat tightness | Pfizer | 3,708 | 2.28 | 1,625.5 |
| Unconsciousness | Janssen | 1831 | 2.26 | 1,177.80 |
| Unresponsive to stimuli | Janssen | 632 | 2.02 | 299.13 |
| Sleep disorder | Janssen | 1,061 | 2.23 | 659.92 |
| Cardiovascular AE (14) Janssen (9) Moderna (1) Pfizer (10) | ||||
| Hypertension | Pfizer | 3,327 | 2.49 | 1754.30 |
| Atrial fibrillation | Moderna | 1,145 | 2.11 | 415.38 |
| Pfizer | 1,251 | 2.50 | 660.61 | |
| Decreased heart rate | Janssen | 144 | 2.02 | 67.81 |
| Heart rate irregular | Pfizer | 943 | 2.63 | 548.00 |
| Increased heart rate | Pfizer | 6,946 | 2.27 | 3,050.10 |
| Palpitations | Pfizer | 7,385 | 2.67 | 4,427.80 |
| Myocardial infarction | Janssen | 162 | 2.11 | 84.57 |
| Pfizer | 740 | 2.35 | 345.59 | |
| Cerebrovascular accident | Janssen | 439 | 2.94 | 498.29 |
| Pfizer | 1,391 | 2.11 | 511.72 | |
| Epistaxis | Janssen | 309 | 2.17 | 178.72 |
| Contusion | Janssen | 644 | 2.03 | 311.33 |
| Pulmonary embolism | Janssen | 584 | 4.57 | 1,351.53 |
| Pfizer | 1,339 | 2.30 | 599.16 | |
| Thrombosis | Janssen | 1,004 | 6.66 | 3,716.05 |
| Pfizer | 1737 | 2.38 | 830.80 | |
| Pulmonary thrombosis | Janssen | 139 | 5.76 | 433.54 |
| Deep vein thrombosis | Janssen | 524 | 5.85 | 1,667.82 |
| Pfizer | 943 | 2.15 | 361.52 | |
| Ear AE (4) Pfizer (4) | ||||
| Deafness | Pfizer | 809 | 2.03 | 269.64 |
| Ear discomfort | Pfizer | 1,362 | 3.00 | 982.30 |
| Hypoacusis | Pfizer | 781 | 2.50 | 411.39 |
| Tinnitus | Pfizer | 6,933 | 2.92 | 4,844.67 |
| Eye AE (2) Janssen (2) | ||||
| Vision blurred | Janssen | 1,136 | 2.81 | 1,178.67 |
| Visual impairment | Janssen | 519 | 2.26 | 332.92 |
| Female reproductive system AE (5) Janssen (4) Pfizer (5) | ||||
| Menstrual disorder | Janssen | 231 | 2.10 | 121.37 |
| Pfizer | 1,436 | 4.18 | 1,592.20 | |
| Dysmenorrhoea | Janssen | 173 | 2.08 | 89.31 |
| Pfizer | 1,090 | 4.25 | 1,230.30 | |
| Heavy menstrual bleeding | Janssen | 444 | 2.49 | 355.35 |
| Pfizer | 2,508 | 4.77 | 3,183.13 | |
| Menstruation irregular | Janssen | 316 | 2.17 | 182.57 |
| Pfizer | 1875 | 4.05 | 2009.78 | |
| Vaginal hemorrhage | Pfizer | 870 | 2.95 | 612.07 |
| Investigation result abnormal AE (1) Pfizer (1) | ||||
| Oxygen saturation decreased | Pfizer | 942 | 2.10 | 340.84 |
| Homeostasis AE (5) Janssen (2) Moderna (2) Pfizer (2) | ||||
| Edema limbs | Moderna | 10,143 | 2.26 | 4,365.30 |
| Pharyngeal edema | Moderna | 1810 | 2.20 | 722.26 |
| Pfizer | 2,313 | 3.49 | 2071.88 | |
| Hongue edema | Pfizer | 2,421 | 2.38 | 1,159.44 |
| Thirst | Janssen | 200 | 2.33 | 136.87 |
| Hypoxia | Janssen | 291 | 2.12 | 157.46 |
| Immune system AE (4) Janssen (1) Pfizer (4) | ||||
| COVID-19 pneumonia | Janssen | 385 | 3.75 | 664.63 |
| Pfizer | 1,412 | 4.06 | 1,517.44 | |
| Myocarditis | Pfizer | 1,542 | 4.09 | 1,669.49 |
| Pericarditis | Pfizer | 975 | 2.93 | 676.20 |
| Lymphadenopathy | Pfizer | 11,810 | 2.29 | 5,303.36 |
| Injury AE (1) Janssen (1) | ||||
| Head injury | Janssen | 310 | 2.07 | 156.62 |
| Local AE (9) Moderna (9) Pfizer (1) | ||||
| Injection-site erythema | Moderna | 5,670 | 11.31 | 12,500.15 |
| Injection-site induration | Moderna | 1,205 | 10.47 | 2,557.19 |
| Injection-site mass | Moderna | 838 | 5.08 | 1,109.98 |
| Injection-site pain | Moderna | 9,006 | 4.08 | 9,701.66 |
| Pfizer | 6,436 | 2.23 | 2,708.10 | |
| Injection-site pruritus | Moderna | 20,473 | 488 | 26,765.79 |
| Injection-site rash | Moderna | 11,805 | 3.71 | 11,407.69 |
| Injection-site reaction | Moderna | 1,160 | 8.68 | 2,240.94 |
| Injection-site swelling | Moderna | 4,312 | 5.54 | 6,180.23 |
| Injection-site warmth | Moderna | 3,011 | 8.62 | 5,805.98 |
| Musculoskeletal or connective tissue AE (2) Janssen (2) Pfizer (1) | ||||
| Muscle spasm | Janssen | 1,298 | 2.62 | 1,168.26 |
| Muscle tightness | Janssen | 272 | 2.27 | 176.34 |
| Pfizer | 1,050 | 2.00 | 337.76 | |
| Nervous system AE (1) Pfizer (1) | ||||
| Paresthesia oral | Pfizer | 3,627 | 2.94 | 2,550.65 |
| Respiratory system AE (4) Janssen (3) Pfizer (2) | ||||
| Acute respiratory failure | Janssen | 204 | 3.11 | 255.31 |
| Pfizer | 840 | 3.68 | 801.76 | |
| Dyspnoea exertional | Janssen | 173 | 2.87 | 186.62 |
| Sinus congestion | Janssen | 133 | 2.11 | 70.86 |
| Respiratory tract congestion | Pfizer | 1916 | 2.33 | 879.76 |
| Serious adverse event (1) Janssen (1) | ||||
| death | Janssen | 919 | 2.02 | 439.26 |
| Skin AE (4) Janssen (2) Moderna (1) Pfizer (2) | ||||
| Flushing | Pfizer | 4,879 | 2.32 | 2,225.60 |
| Hot flushes | Janssen | 462 | 2.38 | 335.43 |
| Pfizer | 1792 | 2.16 | 694.20 | |
| Hyperhidrosis | Janssen | 3,612 | 2.71 | 3,554.09 |
| Rash pruritic | Moderna | 5,336 | 2.08 | 1877.20 |
| Urinary system AE (1) Janssen (1) Pfizer (1) | ||||
| Acute kidney injury | Janssen | 137 | 2.36 | 97.44 |
| Pfizer | 744 | 3.95 | 772.94 | |
Note: see more details in Supplementary Table S1.