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Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variabilities in NASH mice. The pharmacokinetic variabilities of some drugs are mainly caused by alterations in the gut microbiota (A), some may be mainly due to changes in the host Cyp450 enzymes (B), while others are not affected either by the host Cyp450 enzyme or by the gut microbiota (C).
