Table 5.

Comparison of activities and expressions of Cyp450 enzymes determined through different methods.

Cyp450s	AUCmetabolite/AUCparent drug by intragastric administration (in vivo)			AUCmetabolite/AUCparent drug by intravenous administration (in vivo)			Incubation by liver microsomes (in vitro)		Protein expression (in vitro)
	Control	NASH	Change trend	Control	NASH	Change trend	Control	NASH	Control	NASH
Cyp2c29	0.138 ± 0.046	0.031 ± 0.022***	↓	0.241 ± 0.210	0.063 ± 0.034*	↓	−	↓	−	↓
Cyp1a2	4.612 ± 1.017	5.075 ± 1.245	−	0.015 ± 0.008	0.019 ± 0.009	−	−	↓	−	↓
Cyp3a11	8.540 ± 1.215	7.950 ± 1.945	−	0.697 ± 0.331	0.956 ± 0.582	−	−	↓	−	↓
Cyp2c65	0.137 ± 0.056	0.065 ± 0.027**	↓	0.071 ± 0.035	0.034 ± 0.019*	↓	−	↓	−	↓
Cyp2e1	0.986 ± 0.327	0.632 ± 0.527	−	0.093 ± 0.039	0.090 ± 0.055	−	−	−	−	↓
Cyp2d22	0.175 ± 0.090	0.167 ± 0.033	−	0.013 ± 0.005	0.009 ± 0.007	−	−	−	−	−

Note: Data are mean ± SD; *p < 0.05, **p < 0.01, ***p < 0.001 versus control group. −: not significant. ↓: significantly decreased.