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Role of iron in acquisition mechanisms and bacterial biofilm formation. The presence of iron (Fe) can positively or negatively regulate quorum sensing (QS) regulators. A specific iron concentration is necessary for biofilm formation. If not, the presence of iron can inhibit the expression of genes responsible for extracellular protein synthesis, through QS regulators, necessary for bacterial surface adhesion. In addition, biofilm formation can be directly regulated by QS systems.
