Fig. 7.

Functional network map of genes targeted by dysregulated miRNAs in serum exosomes derived from septic patients. (A-C) Functionally grouped networks of enriched biological terms for dysregulated miRNAs in serum exosomes from patients with sepsis (A), severe sepsis (B) and septic shock (C). The functional networks were constructed with the ClueGO plugin in Cytoscape to reveal the connections and differences in the biological processes and signaling pathways associated with the genes that were targeted by the differentially expressed miRNAs in serum exosomes from septic patients. Each node represents an enriched functional term, and the related terms sharing similar associated genes were grouped to reduce redundancy.