Table 1.
Expression of CD226 axis members on human immune populations.
| TIGIT | CD96 | PVRIG | CD226 | |
|---|---|---|---|---|
| CD4+ T cells: Naïve a | +/- | +/- | +/-* | ++ |
| CD4+ T cells: EM a | ++ | +++ | +/-* | +++ |
| CD4+ T cells: CM a | + | ++ | +/-* | +++ |
| CD4+ T cells: TEMRA a | +/- | +/- | ND | ++ |
| CD4+ T cells: Treg a | ++++ | +/- | +/-* | ++ |
| CD4+ T cells: Tfh c | ++ | ND | ND | ND |
| CD8+ T cells: Naïve a,b | +/- | + | +/- | ++ |
| CD8+ T cells: EM a,b | ++ | +++ | +++ | +++ |
| CD8+ T cells: CM a,b | +/- | ++ | + | +++ |
| CD8+ T cells: TEMRA a,b | +++ | + | +++ | ++ |
| MAIT cells a | - | ++ | +* | +++ |
| γδT cells a | +++ | +/- | +* | +++ |
| B cells a | + | +/- | -* | - |
| NK cells a,b | ++ | ++ | ++ | +++ |
| NKT cells (CD56+ T cells) a | ++ | ++ | ND | +++ |
| Myeloid a | - | - | -* | ++ |
Analysis based on human PBMCs. Expression may vary depending on tissue type and indication (e.g., cancer). Symbols (+ and -) represent relative and qualitative expression of each receptor, wherein + is positive expression and – or -/+ is negative or minimal/variegated expression, respectively. ND, not determined. a (11); b (12); c (13); *RNA analysis only (Human Cell Atlas).