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. 2022 Jun;10(11):642. doi: 10.21037/atm-22-2507

Figure 1.

Figure 1

Memantine can reduce the degree of fibrosis in mice with BLM-induced pulmonary fibrosis. (A) HE staining and Masson staining of lung tissue in the sham-operated, memantine, BLM, and BLM + memantine groups (×100, n=5); (B) ashcroft scores of four groups of lung tissue pathological specimens; (C) determination of hydroxyproline content in the four groups of lung tissue samples; (D,E) changes in the protein expression levels of α-SMA, vimentin, E-cadherin, and EpCAM in the four groups of lung tissues. **P<0.01 vs. Sham; ##P<0.01 vs. BLM (n=5). BLM, bleomycin; α-SMA, alpha-smooth muscle actin; EpCAM, epithelial cell adhesion molecule.