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. 2022 Jul 8;13:3937. doi: 10.1038/s41467-022-31600-0

Fig. 3. Cell-type proportion differences between children and adults.

Fig. 3

a–f In silico estimation of cell-type proportions in the bulk RNA-sequencing using single-cell signatures. Color indicates the age cohort. Black lines denote the median. The y-axis in each panel was trimmed at the maximum value among all groups of 1.5*IQR above the third quartile, where IQR is the interquartile range. For each cell type, we formally compared each viral status group between the two age cohorts as well as the No Virus and SARS-CoV-2 groups within each age cohort. Pairwise comparisons were performed with a two-sided Mann-Whitney test followed by Holm’s correction for multiple testing. Adults-No Virus n = 81, Adults-SARS-CoV-2 n = 45, Adults-Other Virus n = 28, Children-No Virus n = 34, Children-SARS-CoV-2 n = 38, Children-Other Virus n = 11. Complete results are provided in Supplementary Data 6.