Table 2.
Baseline characteristics of the study population divided according to the drug prescribed
| Variables | SGLT2i | GLP1RA | Significance |
|---|---|---|---|
| (n = 54) | (n = 113) | ||
| Age (years) | 61.2 ± 10.0 | 63.7 ± 9.1 | p = 0.110 |
| Gender, male [n (%)] | 37 (68.5) | 76 (67.3) | p = 0.870 |
| Weight (kg) | 89.0 ± 20.2 | 92.7 ± 17.1 | p = 0.226 |
| BMI (kg/m2) | 31.1 ± 5.4 | 33.5 ± 6.3 | p = 0.017 |
| Abdominal circumference (cm) | 107.5 ± 15.1 | 112.9 ± 13.0 | p = 0.021 |
| SBP (mmHg) | 127.6 ± 16.4 | 130.0 ± 16.5 | p = 0.405 |
| DBP (mmHg) | 76.0 ± 12.1 | 76.4 ± 9.9 | p = 0.804 |
| Heart rate | 71.9 ± 13.0 | 72.7 ± 10.1 | p = 0.672 |
| Fasting glucose (mg/dl) | 187.6 ± 65.6 | 144.0 ± 37.9 | p < 0.001 |
| HbA1c (mmol/mol) | 71.8 ± 21.0 | 57.8 ± 14.4 | p < 0.001 |
| C-peptide (ng/ml) | 3.0 ± 2.0 | 2.9 ± 1.3 | p = 0.704 |
| HOMA index (n = 84) | 5.3 ± 3.9 | 4.8 ± 3.9 | p = 0.587 |
| Vitamin D (ng/ml) (n = 108) | 19.6 ± 13.6 | 24.6 ± 13.1 | p = 0.062 |
| Creatinine (mg/dl) | 0.85 ± 0.25 | 0.97 ± 0.33 | p = 0.025 |
| e-GFR (ml/min) | 90.5 ± 16.7 | 79.6 ± 21.2 | p = 0.002 |
| BUN (mg/dl) | 40.7 ± 10.9 | 43.6 ± 14.2 | p = 0.240 |
| Uric acid (mg/dl) | 5.3 ± 1.8 | 5.4 ± 1.7 | p = 0.633 |
| Cholesterol (mg/dl) | 149.9 ± 34.6 | 145.3 ± 38.3 | p = 0.469 |
| LDL-cholesterol (mg/dl) | 77.5 ± 29.8 | 75.0 ± 31.2 | p = 0.644 |
| HDL-cholesterol (mg/dl) | 44.5 ± 12.6 | 45.8 ± 13.8 | p = 0.555 |
| Triglycerides (mg/ml) | 165.6 ± 138.0 | 136.9 ± 60.8 | p = 0.070 |
| AST (U/L) | 23.5 ± 14.0 | 25.7 ± 13.3 | p = 0.353 |
| ALT (U/L) | 32.1 ± 23.0 | 35.4 ± 25.3 | p = 0.442 |
| γ-GT (U/L) | 39.1 ± 29.9 | 45.3 ± 41.9 | p = 0.365 |
| U-ACR (mg/g) (n = 104) | 103.5 ± 282.7 | 44.0 ± 97.6 | p = 0.115 |
| SA + LA insulin (IU) (n = 39) | 38.7 ± 23.0 (n = 16) | 35.7 ± 26.9 (n = 23) | p = 0.399 |
Data are presented as mean value ± SD or as frequency and percentage. Statistically significant p values (<0.05) are shown in bold.
Abbreviations: BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycated hemoglobin; HOMA index: fasting glucose × fasting insulin/405; e-GFR: glomerular filtration rate; BUN: blood urea nitrogen; LDL: low density lipoprotein; HDL: high density lipoprotein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; γ-GT: gamma-glutamyl transferase; U-ACR: urine albumin-to-creatinine ratio; SA: short acting; LA: long acting; IU: international units.