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. 2022 Jun;14(6):1772–1783. doi: 10.21037/jtd-21-1377

Table 1. Baseline characteristics.

Patient characteristics All STK11-mutated (n=41) STK11/KRAS co-mutated (n=22) STK11-mutated/KRAS wt (n=19)
Age at diagnosis (years), median (range) 65.4 (47.4 to 87.0) 64.3 (47.4 to 79.8) 67.6 (55.4 to 87.0)
Sex, n [%]
   Male 24 [59] 13 [59] 11 [58]
   Female 17 [41] 9 [41] 8 [42]
Race, n [%]
   African American 1 [2] 0 1 [5]
   White 36 [88] 21 [95] 15 [79]
   Hispanic 2 [5] 0 2 [11]
   Asian 2 [5] 1 [5] 1 [5]
Smoking history
   Current smoker 5 [12] 3 [14] 2 [11]
   Former smoker 34 [83] 18 [82] 16 [84]
   Never smoker 2 [5] 1 [4] 1 [5]
Pack-years in smokers, mean (SD) 36.9 (21.1) 35.8 (18.3) 38.3 (24.4)
ECOG PS at diagnosis
   0–1 32 [78] 17 [77] 15 [79]
   ≥2 9 [22] 5 [23] 4 [21]
Stage at diagnosis, n [%]
   I–II 12 [29] 7 [32] 5 [26]
   III 7 [17] 4 [18] 3 [16]
   IV 22 [54] 11 [50] 11 [58]
Stage IV at any time, n [%] 35 [85] 18 [82] 17 [89]
Brain metastases, n [%] 14 [34] 7 [32] 7 [37]
Histology, n [%]
   Adenocarcinoma 35 [85] 20 [90] 15 [79]
   Squamous 4 [10] 1 [5] 3 [16]
   NSCLC, other 2 [5] 1 [5] 1 [5]
PD-L1 status
   N with PD-L1 known 13 5 8
   ≥50% 3 [23] 2 [40] 1 [13]
   1–50% 4 [31] 1 [20] 3 [37]
   ≤1% 6 [46] 2 [20] 4 [50]
TMB, mutations/Mb
   N with TMB available 39 22 17
   Median TMB, range 8 (1 to 59.2) 6.5 (1 to 21.7) 9 (3.6 to 59.2)
   TMB ≥10, n [%] 15 [38] 7 [32] 8 [47]

SD, standard deviation; ECOG PS, Eastern Cooperative Oncology group scale of performance status; NSCLC, non-small cell lung cancer; TMB, tumor mutation burden.