Table 5. Immune subtypes based on immune gene expression analysis from TCGA data for lung adenocarcinoma.
| Immune subtype | STK11 wild type, n [%] | STK11 mutated, n [%] | STK11/KRAS co-mutated, n [%] | STK11/TP53 co-mutated, n [%] |
|---|---|---|---|---|
| Wound healing (C1) | 10 [8] | 4 [27] | 7 [23] | 3 [20] |
| IFNg dominant (C2) | 28 [34] | 3 [20] | 4 [13] | 7 [37] |
| Inflammatory (C3) | 63 [53] | 6 [40] | 18 [60] | 3 [20] |
| Lymphocyte depleted (C4) | 8 [7] | 2 [13] | 0 [0] | 1 [7] |
| Immunologically quiet (C5) | – | – | – | – |
| TGF-β dominant (C6) | 10 [8] | 0 [0] | 1 [3] | 1 [7] |
TCGA, The Cancer Genome Atlas; IFNg, interferon-gamma; TGF-β, transforming growth factor-beta.