Table 1. Main tumor and patients characteristics.
| Characteristics | Overall (n=119) | E20ID (n=34) | OSUM (n=62) | ECM (n=23) | P value |
|---|---|---|---|---|---|
| Main patient characteristics | |||||
| Sexa | 0.86 | ||||
| Female | 68 (57.0%) | 20 (58.8%) | 36 (58.1%) | 12 (52.2%) | |
| Age, years, mean [SD] | 67 [10] | 70 [10] | 66 [11] | 66 [9] | |
| Smoking status (3 missing values)a | 0.004 | ||||
| Non-smoker | 46 (39.7%) | 20 (58.8%) | 18 (30.0%) | 8 (36.4%) | |
| Current smoker | 27 (23.3%) | 2 (5.8%) | 19 (30.7%) | 6 (26.1%) | |
| Former smoker | 43 (37.0%) | 12 (35.3%) | 23 (37.1%) | 8 (34.8%) | |
| BMI at diagnosis (20 missing values)b | 0.48 | ||||
| Mean | 25.1 | 26.6 | 24.6 | 24.3 | |
| Professional exposure (26 missing values)a | 0.40 | ||||
| Yes | 12 (13.0%) | 5 (14.7%) | 6 (16.2%) | 1 (4.0%) | |
| Performance status if known (13 missing data)a | 0.41 | ||||
| 0–1 | 77 (72.6%) | 24 (70.6%) | 34 (54.8%) | 19 (82.7%) | |
| 2 | 21 (19.8%) | 7 (20.6%) | 9 (14.5%) | 5 (21.7%) | |
| 3 | 8 (7.6%) | 1 (2.9%) | 7 (11.3%) | 0 | |
| Main tumor characteristics | |||||
| Histologya | 0.92 | ||||
| Adenocarcinoma | 111 (93.3%) | 33 (97.1%) | 58 (93.6%) | 20 (87.0%) | |
| Other | 8 (6.7%) | 1 (2.9%) | 6 (9.7%) | 1 (4.3%) | |
| PD-L1 status (% on data available) [45 (38%) missing values]c | 0.86 | ||||
| PD-L1 negative | 33 (44.6%) | 11 (45.8%) | 15 (35.0%) | 7 (41.0%) | |
| PD-L1 positive | 41 (55.4%) | 13 (54.2%) | 21 (49.0%) | 7 (41.0%) | |
| PD-L1 >50% | 14 (19.0%) | 4 (16.0%) | 7 (16.0%) | 3 (18.0%) | |
| Known initial metastasis [2 (1.6%) missing values]a | |||||
| Yes | 93 (78.2%) | 27 (79.4%) | 51 (82.0%) | 15 (71.0%) | 0.66 |
| Cerebral location | 25 (26.8%) | 7 (25.9%) | 17 (27.0%) | 1 (4.0%) | 0.07 |
a, Ki2 Pearson; b, F test; c, Ki2 Pearson on positivity. E20ID, exon 20 insertion/duplication; OSUM, other single uncommon mutation; ECM, EGFR complex mutation; BMI, body mass index; PD-L1, programmed cell death 1 ligand 1.