Table 1. Baseline characteristics and outcomes of 1-year survivors and non-survivors.
| Variables | Total (N=76) | Survivor (N=52) | Non-survivor (N=24) | P |
|---|---|---|---|---|
| Donor variables | ||||
| Age (years) | 40.1±12.6 | 39.7±12.3 | 41.1±13.5 | 0.665 |
| PF ratio | 426.6±120.0 | 434.1±109.0 | 407.5±145.3 | 0.403 |
| TLC DR ratio | 1.0±0.4 | 1.1±0.1 | 0.9±0.7 | 0.286 |
| Recipient variables | ||||
| Age (years) | 56.6±10.3 | 55.2±10.8 | 59.7±8.0 | 0.052 |
| Sex (M) | 48 (63.2) | 32 (61.5) | 16 (66.7) | 0.667 |
| BMI | 21.7±4.3 | 21.2±4.6 | 22.6±3.5 | 0.187 |
| Aetiology | 0.470 | |||
| DILD | 43 (56.6) | 29 (55.8) | 14 (58.3) | |
| COPD | 7 (9.2) | 6 (11.5) | 1 (4.2) | |
| Post-ARDS lung fibrosis | 13 (17.1) | 8 (15.4) | 5 (20.8) | |
| Pulmonary graft versus host disease | 7 (9.2) | 6 (11.5) | 1 (4.2) | |
| Bronchiectasis | 1 (1.3) | 0 | 1 (4.2) | |
| Others | 5 (6.6) | 3 (5.8) | 2 (8.3) | |
| BTT | 60 (78.9) | 39 (75.0) | 21 (87.5) | 0.214 |
| *Adequacy of prophylactic antibiotics | 21 (27.6) | 13 (25.0) | 8 (33.3) | 0.450 |
| Preoperative sputum colonisation | ||||
| Donor | 34 (44.7) | 24 (46.2) | 10 (41.7) | 0.715 |
| Recipient | 28 (36.8) | 16 (30.8) | 12 (50.0) | 0.106 |
| Clinical outcome | ||||
| Early PTP | 37 (48.7) | 20 (38.5) | 17 (70.8) | 0.009 |
| Postoperative VFD within 28 days | 14.5±9.8 | 15.4±9.7 | 12.6±9.9 | 0.264 |
| Postoperative ICU stay (days) | 20.7±17.6 | 15.3±12.6 | 32.3±21.4 | 0.001 |
Data is presented as mean ± standard deviations or number (%). *, adequacy of prophylactic antibiotics. Appropriate antimicrobial treatment is defined as the use of agents with in vitro activity against the etiologic pathogens based on our hospital’s diagnostic laboratory results (18). PF ratio, PaO2/FiO2 ratio; TLC DR ratio, total lung capacity donor/recipient ratio; BMI, body mass index; DILD, diffuse interstitial lung disease; COPD, chronic obstructive pulmonary disease; ARDS, acute respiratory distress syndrome; BTT, bridge to transplantation; PTP, post-transplant pneumonia; VFD, ventilator-free day, defined as days alive and free from mechanical ventilation; ICU, intensive care unit.