Synthesis of 5-functionalized thiophene aminoesters 3a–3l.

Compound	R	Isolated yield (%)
3a	4-CO2Me–Ph–	55
3b	4-NO2–Ph–	65
3c	4-HO–Ph–	64
3d	3-Cl-4-F–Ph–	82
3e	4-Morpholinyl–Ph–	73
3f	4-(N-Methylpiperazinyl)–Ph–	71
3g	4-Piperidinyl–Ph–	71
3h	4-MeS–Ph–	72
3i	4-MeSO2–Ph–	62
3j	4-(H2N–SO2)–Ph–	47
3k	4-(Morpholinyl–SO2)–Ph–	88
3l	2-Chloropyrimidin-5-yl–	44