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Effect of inhibitors and (metal) ions on MLH activity
| Effector | Concn (mM) | Relative activitya (%) |
|---|---|---|
| None | 100 | |
| 2-Bromo-4′-nitroacetophenone | 1 | 16 |
| Phenylhydrazine | 1 | 83 |
| α,α′-Dipyridyl | 1 | 45 |
| EDTA | 10 | 84 |
| SDS | 1 | 22 |
| Dithiothreitol | 1 | 100 |
| Iodoacetate | 1 | 100 |
| p-Chloromercuribenzoate | 0.1 | 74 |
| HgCl2 | 0.1 | 5 |
| CoCl2 | 1 | 29 |
| MnCl2 | 1 | 63 |
| CaCl2 | 1 | 73 |
| MgCl2 | 1 | 100 |
100% = activity with ɛ-caprolactone.
