Table 3. Quality-of-Life Metrics Related to Smell Loss by Study Arm and Study Assessment Using the Questionnaire for Olfactory Disorders.
| Assessmenta | Assessment time point | Theophylline arm (n = 26) | Placebo arm (n = 25) | ||
|---|---|---|---|---|---|
| No. | Median score (range) | No. | Median score (range) | ||
| Quality of life | Baseline | 24 | 17.39 (6.27 to 26.22) | 25 | 15.96 (5.13 to 30.21) |
| 3 weeks | 23 | 15.39 (3.99 to 25.65) | 23 | 12.54 (3.99 to 27.93) | |
| 6 weeks | 22 | 15.39 (4.56 to 25.65) | 23 | 14.25 (2.28 to 26.79) | |
| Baseline to 6 weeks’ change, median difference (95% CI) | 22 | 0.86 (−0.57 to 2.85) | 23 | 1.43 (−0.29 to 3.14) | |
| Quality of life-negative statements | Baseline | 24 | 26.50 (10.00 to 42.00) | 25 | 22.00 (8.00 to 48.00) |
| 3 weeks | 23 | 25.00 (6.00 to 40.00) | 23 | 20.00 (5.00 to 43.00) | |
| 6 weeks | 22 | 25.00 (6.00 to 40.00) | 23 | 22.00 (2.00 to 43.00) | |
| Baseline to 6 weeks’ change, median difference (95% CI) | 22 | 1.50 (−1.00 to 4.50) | 23 | 1.80 (−1.00 to 5.00) | |
| Parosmia | Baseline | 24 | 1.08 (0.36 to 1.44) | 25 | 1.32 (0.00 to 1.44) |
| 3 weeks | 23 | 0.96 (0.00 to 1.44) | 23 | 0.96 (0.00 to 1.44) | |
| 6 weeks | 22 | 1.20 (0.24 to 1.44) | 23 | 1.08 (0.24 to 1.44) | |
| Baseline to 6 weeks’ change, median difference (95% CI) | 22 | −0.06 (−0.18 to 0.06) | 23 | 0.06 (−0.60 to 0.24) | |
| Sincerity | Baseline | 24 | 1.44 (0.36 to 2.70) | 25 | 1.08 (0.18 to 2.52) |
| 3 weeks | 23 | 1.26 (0.18 to 2.70) | 23 | 1.44 (0.00 to 3.24) | |
| 6 weeks | 22 | 1.44 (0.54 to 2.34) | 23 | 1.26 (0.36 to 2.70) | |
| Baseline to 6 weeks’ change, median difference (95% CI) | 22 | 0.00 (−0.09 to 0.18) | 23 | −0.14 (−0.36 to 0.00) | |
a
Higher scores for quality of life, quality of life-negative statements, and parosmia indicate a higher degree of impairment. Lower scores for sincerity suggest a greater tendency to give socially desirable answers.