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. Author manuscript; available in PMC: 2022 Aug 25.
Published in final edited form as: J Am Chem Soc. 2021 Aug 13;143(33):13044–13055. doi: 10.1021/jacs.1c02248

Figure 1.

Figure 1.

Inforna-based reprogramming of the ReFRAME small-molecule library by identifying RNA binders. (A) Left, secondary structure of the 1024-member 3×2 RNA internal loop library (3×2 ILL) and summary of the 9300-member ReFRAME library. Right, the library-versus-library screen probes over 9,500,000 combinations of RNA motif–small molecule interactions to identify the privileged RNA structures that bind small-molecule medicines with high affinity. (B) Inforna-based identification of Dovitinib (1) targeting pre-miR-21’s Dicer site, which inhibits its processing and hence its oncogenicity.