Skip to main content
. Author manuscript; available in PMC: 2022 Aug 25.
Published in final edited form as: J Am Chem Soc. 2021 Aug 13;143(33):13044–13055. doi: 10.1021/jacs.1c02248

Figure 3.

Figure 3.

Rationale of selective inhibition of miR-21 by RIBOTAC 4. Top, experimental flowchart of how selective inhibition of miR-21 by RIBOTAC 4 was assessed. Bottom, scheme of factors that contribute to RIBOTAC activity and selectivity, including: occupancy of the target by the RNA-binding module (e.g., 1); expression level of the target where more abundant targets are occupied to a greater extent than less abundant ones; and the juxtaposition of the site bound by the RNA-binding module and a site sensitive to RNase L cleavage (unpaired UNN) and the distance between them.